Mamoru Tasaki Selected Research

Protein Kinase C-theta

1/2019	Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions.
11/2018	A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant model.
7/2015	Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.

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Mamoru Tasaki Research Topics

Disease

3	Neoplasms (Cancer) 12/2021 - 01/2020
2	Rheumatoid Arthritis 01/2019 - 07/2015
2	Autoimmune Diseases (Autoimmune Disease) 11/2018 - 12/2014
2	Inflammation (Inflammations) 12/2014 - 06/2013
1	Extranodal Extension 01/2020
1	Arthritis (Polyarthritis) 12/2014
1	Respiratory Hypersensitivity 06/2013
1	Asthma (Bronchial Asthma) 06/2013
1	Blindness (Hysterical Blindness) 01/2003
1	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 01/2003

Drug/Important Bio-Agent (IBA)

3	Interleukin-7 (Interleukin 7)IBA 12/2021 - 01/2020
3	Interleukin-12 (IL 12)IBA 12/2021 - 01/2020
3	Protein Kinase C-thetaIBA 01/2019 - 07/2015
2	Immune Checkpoint InhibitorsIBA 12/2021 - 01/2020
2	Pharmaceutical PreparationsIBA 12/2014 - 06/2013
1	CTLA-4 AntigenIBA 01/2020
1	Immunosuppressive Agents (Immunosuppressants)IBA 12/2014
1	AS2521780IBA 12/2014
1	AntigensIBA 06/2013
1	ASP5642IBA 06/2013
1	ramatrobanIBA 06/2013
1	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 06/2013
1	Retinaldehyde (Retinal)IBA 01/2003

Therapy/Procedure

1	Immunotherapy 01/2020